Changing the Notepad++ default file save location is easy but the issue I ran into was the Update Notepad++ function was not working in the version of Notepad++ I was running. So I was attempting to modify the default save location which was not yet possible in the version I was using. Finally I decided to check the web site to see if a new version was available and sure enough I was running version 4.9.x and the current release was Notepad++ version 5.2.
After upgrading to Notepad++ version 5.2 more options were available to modify file save/open locations and behavior. As shown below in the image there are now three basic options to control what directory Notepad++ looks to by default for opening and saving files.